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What Is the Difference Between Melanocytic Nevi and Melanoma?
We know that although melanocytic nevi and melanoma have similar names, their natures are completely different. So what is the difference between them?
2025/09/04
We know that although melanocytic nevi and melanoma have similar names, their natures are completely different. So what is the difference between them?
Zhang Bing, Department of Dermatology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine: Despite the difference of just one word, they are entirely different. Despite the difference of just one word, they are entirely different. One is a benign tumor formed by the aggregation of melanocytes, while the other is a malignant tumor formed by the cancerous transformation of melanocytes.
Melanocytic nevi grow slowly, often worsen due to sun exposure, do not metastasize, and can appear anywhere on the body, commonly in exposed areas. They are symmetrically shaped, have clear boundaries, uniform color, and are generally less than 5 mm in diameter. They usually cause no subjective symptoms.
Melanoma often grows rapidly and may be associated with a family history of skin cancer, excessive sun exposure, or immunodeficiency. It is prone to metastasis and often occurs in acral areas such as the extremities, ends of the hands and feet, or under the nails. It is typically asymmetrical in shape, has irregular edges, muddy or variegated colors, and is usually larger than 5 mm in diameter. The surface may ulcerate, and satellite lesions may appear around it. It can cause subjective symptoms such as itching and pain.
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